Sökning: "Hyun-jin Kim"

Hittade 1 avhandling innehållade orden Hyun-jin Kim.

1. 1. LXR and aromatase knock-out mice : animal models providing insight into human diseases

   Författare :Hyun-Jin Kim; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. LÄS MER