Sökning: "Hypoxia-Inducible Factor 1 metabolism"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Hypoxia-Inducible Factor 1 metabolism.

  1. 1. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia

    Författare :Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. LÄS MER

  3. 2. Hypoxia inducible factor-1α in renal cell carcinoma

    Författare :Anders Lidgren; Börje Ljungberg; Torgny Rasmuson; Kjell Grankvist; Anders Bergh; Per-Uno Malmström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal cell carcinoma; hypoxia; RT-PCR; angiogenesis; western blot; tissue microarray; protein; mRNA; HIF-1 alpha; GLUT-1; survival; Urology and andrology; Urologi och andrologi;

    Sammanfattning : Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). LÄS MER

  4. 3. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

    Författare :Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

    Sammanfattning : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. LÄS MER

  5. 4. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma

    Författare :Matilda Thorén; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small cell lung carcinoma; arsenic trioxide; hypoxia; hypoxia-inducible factors; survival; proliferation; glycolysis; glutamine metabolism; MYC;

    Sammanfattning : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. LÄS MER

  7. 5. Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation

    Författare :Xiaohui Jia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) mainly mediates this critical adaptation. LÄS MER