Sökning: "Human pluripotent stem cells"

Visar resultat 1 - 5 av 69 avhandlingar innehållade orden Human pluripotent stem cells.

  1. 1. Human embryonic stem cells : : A novel model system for early human development

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Karin Gertow; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; Human embryonic stem cells; model system; differentiation; xeno-grafting; teratoma; development; karyotype; chromosomal integrity; variant.;

    Sammanfattning : Human embryonic stem cells (HESC) have since their first description in 1998 been recognized as a theoretically endless source of cells capable of differentiation into any somatic cell type. Although great attention has been given to their potential use in cell-based therapy, they are equally important as research tools for studies on early human development, both normal and diseased. LÄS MER

  2. 2. Towards Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells

    Detta är en avhandling från Lund University, Faculty of Medicine, Institution of Laboratory Medicine, Division of Molecular Medicine and Gene Therapy

    Författare :Roger Rönn; Lund University.; Lunds universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; pluripotent stem cells; embryonic development.; in vitro differentiation;

    Sammanfattning : There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. LÄS MER

  3. 3. Inflammation and Stem Cell Therapy for Stroke

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Ruimin Ge; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. LÄS MER

  4. 4. Generation of cortical neurons through reprogramming technology

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Giedre Miskinyte; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Nyckelord :Cortex; Reprogramming; human ES cells; transcription factor programming; cortical projection neurons; Human adult cortical slices;

    Sammanfattning : The human cortex is affected by several debilitating acute and chronic neurodegenerative disorders such as stroke, traumatic brain injury, amyotrophic lateral sclerosis and Alzheimer’s disease, which target specific types of cortical neurons. Emerging evidence indicates that stem cells and reprogrammed cells can be used to generate human cortical neurons both for cell replacement by transplantation, and for disease modeling and drug screening. LÄS MER

  5. 5. Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Carolina Guibentif; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human pluripotent stem cells; Embryonic Development; endothelial-to-hematopoietic transition; Hematopoiesis;

    Sammanfattning : The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. LÄS MER