Sökning: "Human genome"

Visar resultat 11 - 15 av 683 avhandlingar innehållade orden Human genome.

  1. 11. Computational exploration of human genome variation

    Författare :David Fredman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :SNP; polymorphism; database; genotyping; duplication; haplotype;

    Sammanfattning : In studies of human genome variation, researchers attempt to identify the DNA sequence differences between our genomes that contribute substantially to variation that can be observed on a physical level (phenotype). Genetic variation can also be used to study population dynamics in human history, and how evolutionary forces have shaped the human genome. LÄS MER

  3. 12. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution

    Författare :Jonas Berglund; Matthew Webster; Kerstin Lindblad-Toh; Leif Andersson; Nadia Singh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; biased gene conversion; CpG island; copy number variation; substitutions; methylation; Bioinformatics; Bioinformatik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER

  4. 13. Genome dynamics and virulence in the human pathogen Candida glabrata

    Författare :Khadija Mohamed Ahmad; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pathogenic yeast; Candida glabrata; small chromosomes; Genome rearrangement; Haploid and diploid yeast; RNA interference.;

    Sammanfattning : Although the yeast Candida glabrata is considered to be a part of the commensal microflora in healthy individuals, during the last years it has been frequently isolated from patients with mucosal and systemic fungal infections. Now it is considered as the second most frequently isolated pathogenic yeast after Candida albicans. Despite its name, C. LÄS MER

  5. 14. Bioremediation of Toxic Metals for Protecting Human Health and the Ecosystem

    Författare :Aminur Rahman; Abul Mandal; Jana Jass; Björn Olsson; Pawel Kaszycki; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Heavy Metals; Pollution; Accumulation; Remediation; Human Health; Bacteria; Genome Sequencing; de novo Assembly; Gene Prediction; Biology; Biologi; Bioteknik;

    Sammanfattning : Heavy metal pollutants, discharged into the ecosystem as waste by anthropogenic activities, contaminate drinking water for millions of people and animals in many regions of the world. Long term exposure to these metals, leads to several lethal diseases like cancer, keratosis, gangrene, diabetes, cardio- vascular disorders, etc. LÄS MER

  7. 15. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
    Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER