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Visar resultat 1 - 5 av 178 avhandlingar som matchar ovanstående sökkriterier.
1. Wnt-5a Signalling in Human Mammary Cells: Implications for the Development of Breast Cancer
Sammanfattning : The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. LÄS MER
2. Immune Tolerance Mechanisms in Human Breast Cancer
Sammanfattning : .... LÄS MER
3. Stem and progenitor cells in brain ad breast malignancies
Sammanfattning : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. LÄS MER
4. Genetic characterization of malignant melanoma and breast cancer
Sammanfattning : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. LÄS MER
5. Cyclin E overexpression and associated events in human breast cancer
Sammanfattning : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. LÄS MER