Sökning: "Human Protein Atlas"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden Human Protein Atlas.

1. 16. Protein Expression Profiling of Cancer Biomarkers

   Författare :Kristina Magnusson; Fredrik Pontén; Karin Jirström; Anna Dimberg; Tibor Tot; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody-based proteomics; Biomarker; SATB2; Colorectal cancer; ANLN; Breast cancer; CD93; Angiogenesis; Pathology; Patologi;

   Sammanfattning : The Human Protein Atlas project is a Swedish research initiative that uses antibody-based proteomics for large scale protein profiling in human tissues and cells. Affinity-purified antibodies are produced within the project and used for immunohistochemical staining on tissue micro arrays (TMAs) in order to map the human proteome and publish the result in a protein atlas (www. LÄS MER

3. 17. Evolution and viral mimicry of short linear motif-mediated interactions

   Författare :Filip Mihalič; Per Jemth; Leo James; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phage display; protein-protein interactions; large-scale discovery; short linear motifs; viral mimcry; viral hijacking; Biokemi; Biochemistry; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : Proteins are one of the most fundamental building blocks of life and their interactions regulate every cellular process. Historically they have been conceptualized as predominantly folded entities with well-defined secondary and tertiary structures. LÄS MER

4. 18. Towards a deeper understanding of the human brain

   Författare :Evelina Sjöstedt; Mathias Uhlén; Jan Mulder; Caroline Kampf; Elly Hol; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain; organization; RNA; classification; mapping; proteins; antibodies; Bioteknologi; Biotechnology;

   Sammanfattning : Identifying the proteome variation in different parts of the body provides fundamental molecular details, enabling further findings and mapping of tissue specific proteins. By combining quantitative transcriptomics with qualitative antibody based proteomics, the Human Protein Atlas (HPA) project aims to protein profile each human protein-coding gene. LÄS MER

5. 19. Aspects of Gene Expression Profiling in Disease and Health

   Författare :Julia Bergman; Fredrik Pontén; Lars Akslen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; biomarkers; differential diagnostics; immunohistochemistry; transcriptomics; protein profiling; adrenal gland.; Pathology; Patologi;

   Sammanfattning : The aim of this thesis is to in various ways explore protein expression in human normal tissue and in cancer and to apply that knowledge in biomarker discovery.In Paper I the prognostic significance of RNA-binding motif protein 3 (RBM3) is explored in malignant melanoma. LÄS MER

7. 20. Multiplexed absolute quantification of blood plasma proteins using targeted proteomics

   Författare :David Kotol; Mathias Uhlén; Edfors Fredrik; Roman Zubarev; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; targeted proteomics; stable isotope standards; recombinant protein standards; absolute quantification; blood plasma; multiplex analysis; plasma profiling; Biotechnology; Bioteknologi;

   Sammanfattning : Proteins are the molecular building blocks of all living organisms. They are the functioning actors in metabolism and communication, and they give specific architecture and purpose to all tissues. Their abundance is dynamic and can be interpreted and associated to different physiological states or diseases. LÄS MER