Sökning: "Human C4b-binding protein"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Human C4b-binding protein.
1. Structural and functional studies of C4b-binding protein (C4BP)
Sammanfattning : The subject of this thesis is complement inhibitor C4b-binding protein (C4BP), on which we have performed both structural and functional studies. Complement is part of the innate immune defence and eliminates microbes, solubilises immune complexes and is involved in the clearance of apoptotic cells. LÄS MER
2. Interactions between Streptococcus pyogenes and the human immune system, with special reference to C4b-binding protein
Sammanfattning : The ability of many pathogenic microorganisms to cause infection is dependent on their ability to evade attack by the complement system of the host. One mechanism by which microorganisms may avoid complement attack is to bind complement inhibitory molecules present in the host. LÄS MER
3. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S
Sammanfattning : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. LÄS MER
4. Streptococcal M protein and human C4BP
Sammanfattning : Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. LÄS MER
5. Structural pathology and functional analysis of vitamin K-dependent protein S
Sammanfattning : Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. LÄS MER