Sökning: "Human Adipocytes"

Visar resultat 16 - 20 av 113 avhandlingar innehållade orden Human Adipocytes.

  1. 16. AMP-activated protein kinase in adipose tissue

    Författare :Franziska Kopietz; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPK; adipose tissue; adipocytes; diabetes; insulin; glucose uptake; lipolysis; FA synthesis; ADaM site activators;

    Sammanfattning : The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. LÄS MER

  3. 17. Zinc Oxide Nanostructure Based Electrochemical Sensors and Drug Delivery to Intracellular Environments

    Författare :Muhammad Asif; Magnus Willander; Omer Nour; Sunil Bhand; Linköpings universitet; []
    Nyckelord :ZnO nanorods; Intracellular electrochemical sensor; Functionalization; Metal ions; Glucose; Human Adipocytes; Frog Oocytes; Airway surface liquid; NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : The nanoscale science and nanostructure engineering have well established in the fabrication of novel electrochemical biosensors with faster response and higher sensitivity than of planar sensor configurations. Moreover nanostructures are suggested and used as efficient carrier of photosensitizers for cancerous cell treatment. LÄS MER

  4. 18. The role of galectin-1 in type 2 diabetes. Clinical and experimental studies

    Författare :Emanuel Fryk; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin-1; type 2 diabetes; human; adipose tissue; metabolism;

    Sammanfattning : Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and mass-spectrometry, we found increased galectin-1 levels in the subcutaneous adipose tissue in a small experimental study of 15 men with and without type 2 diabetes. LÄS MER

  5. 19. Microarray analysis of gene expression in human adipocytes and adipose tissue

    Författare :Margareta Jernås; Göteborgs universitet; []
    Nyckelord :obesity; adipose tissue; insulin resistance; serum amyloid A; NAD P H:quinone oxidoreductase 1; Zinc-alpha2 glycoprotein; cell death-inducing DFFA-like effector A; DNA microarray;

    Sammanfattning : Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine and immune functions through the release of adipokines. LÄS MER

  7. 20. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)

    Författare :Meenu Rohini Rajan; Peter Strålfors; Mats Söderström; Olga Göransson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. LÄS MER