Sökning: "HtrA2"

Hittade 3 avhandlingar innehållade ordet HtrA2.

  1. 1. Functional details of human HtrA2 protease studied by NMR spectroscopy

    Författare :Emelie E. Aspholm; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HtrA2; nuclear magnetic resonance; protein quality control; neurodegenerative disease; apoptosis;

    Sammanfattning : Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function in the PQC by degrading damaged and aggregated proteins as well as by acting as molecular chaperones. LÄS MER

  3. 2. Genes involved in Parkinson's disease : focus on mitochondrial and detoxifying enzymes

    Författare :Anna Anvret; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson's disease is a common progressive neurodegenerative disorder which mostly affects the elderly population, with a prevalence of more than 1.5% in the population over the age of 65 years. Clinical motor symptoms are mainly caused by degeneration of dopamine neurons in substantia nigra pars compacta. LÄS MER

  4. 3. Neurodegenerative diseases studied in human brain and rodent models

    Författare :Sandra Gellhaar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s and Alzheimer’s disease are the two most common neurodegenerative diseases world-wide, but are still little understood. Papers in this thesis examine some of the possible pathogenic mechanisms with the help of mouse models and analysis of human post-mortem tissue. LÄS MER