Sökning: "Hsp90"

Visar resultat 16 - 20 av 29 avhandlingar innehållade ordet Hsp90.

  1. 16. Discovering and targeting the mechanisms that govern age-related decline

    Författare :Xin-Xuan Lin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aging is recognized as a major risk factor for many diseases. Thus, the identification of a means to target aging would bear great potential to improve human health and quality of life. LÄS MER

  3. 17. Assessment of prognostic markers in benign and malignant melanocytic tumours

    Författare :Vitalijs Svjatoha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past decade a significant progress has been made in the understanding of genesis and progression of melanocytic lesions. LÄS MER

  4. 18. Cancer proteomics : characterisation of protein expression in human epithelial tumours

    Författare :Ayodele A Alaiya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Two-dimensional gel electrophoresis; protein expression; mass spectrometry; epithelial tumour; heterogeneity;

    Sammanfattning : Defining differences in protein expression between tumour cells of various degrees of malignancy is a first step in the development of markers for tumour diagnosis. In this thesis, the expression of multiple proteins in benign and malignant human ovarian, breast and prostate tumours was examined using two-dimensional gel electrophoresis (2-DE). LÄS MER

  5. 19. Profiling of Small Intestine Neuroendocrine Tumors

    Författare :Ellinor Andersson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumor; somatic copy number alteration; expression profiling; APLP1; survival; targeted therapy;

    Sammanfattning : Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized disease. For most patients the disease follows a progressive and fatal course. LÄS MER

  7. 20. Effects and mechanisms of actions of cyclosporin, FK506 and 15-deoxyspergualin

    Författare :Anette Johansson Borg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cyclosporin; FK506; 15-deoxyspergualin; immunosuppressive effects; transplantation;

    Sammanfattning : Immunosuppressive drugs can be used to deal with unwanted or inappropriate immune reactions, such as the rejection of a transplanted organ. However, treatment with these drugs are often associated with serious adverse effects, and therefore less toxic immunosuppressants are desired. LÄS MER