Sökning: "Hsp90"
Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet Hsp90.
11. Inducible and constitutive modes of gene regulation by the dioxin receptor and Arnt
Sammanfattning : Heterodimeric complexes between the basic helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) transcription factors, dioxin receptor and Arnt, are involved in mediating cellular responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). The unliganded dioxin receptor is found in the cytoplasm complexed with the 90-kDa heat shock protein hsp90, in a latent inactive (non-DNA binding) configuration. LÄS MER
12. DNA vaccines and bacterial DNA in immunity
Sammanfattning : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. LÄS MER
13. Regulation of dioxin receptor activity by phosphorylation and protein-protein interaction
Sammanfattning : The dioxin receptor together with its partner factor Arnt belongs to the basic helix-loop-helix/PAS family of transcription factors. The receptor is the mediator of the biological effects of a number of environmental pollutants such as dioxin and other related compounds. LÄS MER
14. Therapeutic response in human cancers : the dual role of STAT signalling
Sammanfattning : STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects by regulating gene transcription. LÄS MER
15. Mechanisms of regulation of dioxin receptor function
Sammanfattning : The dioxin receptor is a ligand-inducible transcription factor that belongs to the basic helix-loop- helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The dioxin receptor is regulated in a spatial manner, where the unliganded dioxin receptor resides in the cell cytoplasm in a complex with heat shock protein 90 (hsp90). LÄS MER