Sökning: "Host defense peptides"
Visar resultat 1 - 5 av 51 avhandlingar innehållade orden Host defense peptides.
1. Bacteria-host cell interactions : Studies on initial colonization, antimicrobial peptides, and biofilms
Sammanfattning : The obligate human pathogen Neisseria meningitidis asymptomatically colonizes the upper respiratory tract, but crossing of the epithelial barrier can cause life-threatening meningitis and/or sepsis. N. LÄS MER
2. Novel actions of thrombin-derived host defense peptides
Sammanfattning : Thrombin-derived C-terminal peptides (TCPs) constitute a novel class of immunomodulatory host defense peptides, generated during infection and inflammation. Previous investigations have shown that TCPs of 2-3 kDa inhibit pro-inflammatory immune responses in vitro and in vivo, but their mode of action remained unclear. LÄS MER
3. HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
Sammanfattning : Prevention and control of infectious diseases is seriously hampered by an increasing prevalence of bacteria that are resistant towards conventional antibiotics. Resistant bacteria are often the root cause of infections that trigger the complex clinical syndrome called sepsis, which is a concern for high morbidity and mortality. LÄS MER
4. Antibacterial peptides - key players in host defense at epithelial surfaces
Sammanfattning : Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. LÄS MER
5. Effects of the host defense peptide LL-37 on human cells : Immunomodulation and cytotoxicity
Sammanfattning : The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LÄS MER