Sökning: "Hormone refractory"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Hormone refractory.
1. Scintigraphic characterisation of hormone-refractory prostatic adenocarcinoma : aspects of neuroendocrine differentiation : by Karl Mikael Kälkner
Sammanfattning : .... LÄS MER
2. Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1
Sammanfattning : Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer since prostate tumors initially are dependent on androgens for growth. However, most tumors will eventually relapse and grow in a highly aggressive and androgen-independent (AI) manner. LÄS MER
3. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes
Sammanfattning : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. LÄS MER
4. Metastatic spinal cord compression in prostate cancer : clinical and morphological studies
Sammanfattning : Background: Bone metastases occur in most patients with advanced hormone-refractory prostate cancer causing pain, pathologic fractures, and spinal cord compression. Few studies specifically address surgical treatment of metastatic spinal cord compression (MSCC) in prostate cancer. LÄS MER
5. Prostate cancer and neuroendocrine differentiation. Molecular aspects in prostate cancer development
Sammanfattning : Hormone refractory prostate cancer occurs when androgen-deprivation therapy (ADT) fails to stop the growth of prostate cancer for any longer. Recent studies point towards a role for neuroendocrine (NE) differentiation in the development of hormone refractory disease. LÄS MER