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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Probabilistic Modelling of Domain and Gene Evolution

   Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

   Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER

3. 2. From genomes to post-processing of Bayesian inference of phylogeny

   Författare :Raja Hashim Ali; Lars Arvestad; Dannie Durand; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bayesian inference; Computer Science; Datalogi;

   Sammanfattning : Life is extremely complex and amazingly diverse; it has taken billions of years of evolution to attain the level of complexity we observe in nature now and ranges from single-celled prokaryotes to multi-cellular human beings. With availability of molecular sequence data, algorithms inferring homology and gene families have emerged and similarity in gene content between two genes has been the major signal utilized for homology inference. LÄS MER

4. 3. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER

5. 4. Assignment and assessment of orthology and gene function

   Författare :Christian Storm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Orthology; paralogy; homology; bootstrap; tree reconciliation; Pfam; functional annotation;

   Sammanfattning : Several genomes from different species have been sequenced over the last years, most notably the human genome. An important task of computational biology is to classify and functionally annotate the large amount of sequence data created by the genome sequencing projects. LÄS MER

7. 5. Evolutionary Approaches to Sequence Alignment

   Författare :Marcin Bogusz; Simon Whelan; Jeffrey Thorne; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular evolution; multiple sequence alignment; pair hidden Markov models; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Sammanfattning : Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. LÄS MER