Sökning: "Histone deacetylase inhibitor"
Visar resultat 21 - 24 av 24 avhandlingar innehållade orden Histone deacetylase inhibitor.
21. Identification of novel inducers for LL-37 expression : assay development and mechanistic studies
Sammanfattning : The remaining reservoir of effective antibiotics is running out and more and more pathogens are gaining resistance, even to the last line of antibiotics. Therefore, novel treatment regimens against bacterial infections are urgently needed. LÄS MER
22. Novel aspects of metabolic regulation and inflammation in human adipocytes
Sammanfattning : The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. LÄS MER
23. Small molecules that affect the p53 pathway and their potential use in the treatment of cancer
Sammanfattning : The tumor suppressor p53 was identified 35 years ago and has since then been studied extensively, but despite all efforts, no drug or therapy directly involving it has been clinically approved - yet! A lot of potential new drugs are on their way that can reactivate p53 function by various mechanisms. Even a whole new approach called cyclotherapy has been established, during which p53 is activated in normal cells to protect patients from the adverse effects of chemotherapy while tumor cells are still being killed efficiently. LÄS MER
24. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase
Sammanfattning : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. LÄS MER
