Sökning: "Histone Deacetylases"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Histone Deacetylases.
1. Histone deacetylases and their co-regulators in schizosaccharomyces pombe
Sammanfattning : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. LÄS MER
2. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
Sammanfattning : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. LÄS MER
3. Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe
Sammanfattning : The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs to be modified by chromatin remodelling or, by reversible post-translational modifications. LÄS MER
4. Genome-wide patterns of histone modifications in fission yeast
Sammanfattning : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. LÄS MER
5. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors
Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER