Sökning: "High throughput biology"

Visar resultat 6 - 10 av 204 avhandlingar innehållade orden High throughput biology.

  1. 6. Sequence- and structure guided engineering of proteins and enzymes for biotechnology and health applications

    Författare :Karen Schriever; Per-Olof Syrén; Elton P. Hudson; Eric A. Gaucher; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein engineering; enzymology; ancestral sequence reconstruction; antigen engineering; structural biology; terpene cyclases; enzyme thermodynamics; biocatalysis; phosphatases; allosteric regulation; Biotechnology; Bioteknologi;

    Sammanfattning : Proteins are highly diverse and sophisticated biomolecules that represent a cornerstone of biological structure and function and have been exploited in man-made applications for thousands of years. Those proteins that facilitate chemical reactions at physiologically relevant time-scales are referred to as enzymes. LÄS MER

  2. 7. Machine Learning Enabled Functional Discovery in Yeast Systems Biology

    Författare :Daniel Brunnsåker; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Metabolic Modelling; Mass Spectrometry; Metabolism; Metabolomics; Machine Learning; Systems Biology; Inductive Logic Programming; Proteomics;

    Sammanfattning : Saccharomyces cerevisiae is a well-studied organism, yet roughly 20 percent of its proteins remain poorly characterized. Recent studies also seem to indicate that the pace of functional discovery is slow. LÄS MER

  3. 8. Droplet microfluidics for high throughput biological analysis

    Författare :Håkan Jönsson; Helene Andersson-Svahn; Andrew Griffiths; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microfluidics; Droplet microfluidics; High throughput biology; Single cell analysis; Hydrodynamic separation; Enzyme amplification; Fluorescence polarization; Microfabrication; Bioengineering; Bioteknik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Many areas of biological research increasingly perform large-scale analyses.  In genomics the entire gene repertoire of an organism is analyzed.  Proteomics attempts to understand the function and expression patterns of all proteins in a cell or organism. LÄS MER

  4. 9. High-throughput DNA Sequencingin Microbial Ecology : Methods and Applications

    Författare :Luisa Hugerth; Anders Andersson; Jeroen Raes; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Microbial ecology; Baltic Sea; Next-generation sequencing; Amplicon sequencing; Metagenomics; Bioteknologi; Biotechnology;

    Sammanfattning : Microorganisms play central roles in planet Earth’s geochemical cycles, in food production, and in health and disease of humans and livestock. In spite of this, most microbial life forms remain unknown and unnamed, their ecological importance and potential technological applications beyond the realm of speculation. LÄS MER

  5. 10. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation

    Författare :Kristian Björk Grimberg; Patrick Young; Neus Visa; Lars Thelander; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteasome; ubiquitin; p97; unfolding; regulation; RNAi screen; high-throughput screen; cnc; basic leucine zipper; transcription factors; proteasome inhibition; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. LÄS MER