Sökning: "High shear granulation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden High shear granulation.

  1. 1. Fluid Dynamics and Granular Growth in High Shear Wet Granulation

    Författare :Anders Darelius; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Coalescence kernel; Frictional Stress Models; Laser Doppler Anemometry; Population balances; CFD; EFD; High shear granulation; High speed imaging; Multi-dimensional; Multiphase flows;

    Sammanfattning : High shear wet granulation is a key step in the manufacturing of tablets in the pharmaceutical industry. From the pharmaceutical industry’s point of view, there is a desire for predictive quantitative process models to be able to make in-silico process and scale-up simulations, which would shorten and reduce the cost of technology transfer from laboratory scale to manufacturing scale in drug development. LÄS MER

  3. 2. Rheological modeling of particle flows in high shear granulation

    Författare :Mohammad Khalilitehrani; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; continuum modeling; rheology; disc impeller; high shear granulation;

    Sammanfattning : High shear granulation is an important process in a wide variety of applications, more specifically in pharmaceutical industries as a basic step in the tableting process. The process includes two major steps: dry high shear granulation and wet high shear granulation. It aims at producing granules with a specific size and material composition. LÄS MER

  4. 3. Continuum modeling of particle flows in high shear granulation

    Författare :Per Abrahamsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; High shear granulation; parameter study; resolution dependence; continuum modeling; kinetic theory of granular flow; granular flow;

    Sammanfattning : High shear granulation is an important process in the pharmaceutical industry. The aim of the process is to produce granules with specific properties, like size and hardness, from powder mixtures. The properties of the granules are determined by the flow field in the mixer. LÄS MER

  5. 4. Continuum modelling of particle flows in high shear granulation

    Författare :Per Abrahamsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; parameter study; High shear granulation; continuum modelling; resolution dependence; granular flow; compartment model; kinetic theory of granular flow;

    Sammanfattning : High shear granulation is an important process in the pharmaceutical industry. The aim of the process is to produce granules with specific properties, like size and hardness, from powder mixtures. The properties of the granules are determined by the flow field in the mixer. LÄS MER

  7. 5. Population balance modelling of the high shear wet granulation process

    Författare :Anders Jansson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : .... LÄS MER