Sökning: "High Content Screening"
Visar resultat 1 - 5 av 91 avhandlingar innehållade orden High Content Screening.
1. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation
Sammanfattning : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. LÄS MER
2. Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology
Sammanfattning : Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. LÄS MER
3. Healthy women or risk patients? : Non-attendance in a cervical cancer screening program
Sammanfattning : Women afflicted with cervical cancer who have the highest morbidity and mortality rates have been the least likely to be screened. The overall aim of this research project was to investigate non-attendance in a cervical cancer screening (CCS) program among women with no registered cervical smear during the previous five years. LÄS MER
4. Women’s participation in mammography screening
Sammanfattning : This dissertation focuses on women’s participation in mammography screening, which is a vital component of early detection and effective management of breast cancer. All Swedish women in the age group of 40-74 receive an invitation by mail at regular intervals of 18-24 months. LÄS MER
5. Visualization of Protein Activity Status in situ Using Proximity Ligation Assays
Sammanfattning : In 2001 the human proteome organization (HUPO) was created with the ambition to identify and characterize all proteins encoded in the human genome according to several criteria; their expression levels in different tissues and under different conditions; the sub-cellular localization; post-translational modifications; interactions, and if possible also the relationship between their structure and function.When the knowledge of different proteins and their potential interactions increases, so does the need for methods able to unravel the nature of molecular processes in cells and organized tissues, and ultimately for clinical use in samples obtained from patients. LÄS MER