Sökning: "Heterogeneous assay"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden Heterogeneous assay.

  1. 1. Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease

    Författare :Jenny Klintman; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hemophilia A; inhibitors; non-neutralizing anti-FVIII antibodies; thrombin generation assay; ELISA;

    Sammanfattning : Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. LÄS MER

  3. 2. Essays in public finance

    Författare :Tatiana Damjanovic; Handelshögskolan i Stockholm; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Sammanfattning : This thesis consists of four independent essays grouped in two parts. The first part analyzes the possibility and duration of a Pareto-improving pension reform. The second part considers some economic issues related to the tax avoidance activities. The possibility and duration of a Pareto-improving pension reform. LÄS MER

  4. 3. Design of a rapid point-of-care immunoassay : Based on a single-step non-competitive immunoassay with magnetic permeability detection

    Författare :Filiz Ibraimi; Tillämpad biokemi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Superparamagnetic nanoparticles; magnetic permeability; two-site immunoassay; point-of-care; diagnostic test; biomarkers;

    Sammanfattning : This thesis describes the development of a one-step, specific, cost-effective and rapid in vitro point-of-care immunoassay test based on a unique magnetic immunoassay principle. The principle in question is based on a non-competitive heterogeneous immunoassay in a one-step analysis, relying on magnetic permeability detection. LÄS MER

  5. 4. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

    Författare :Mattias Brofelth; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

    Sammanfattning : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. LÄS MER

  7. 5. DNA repair and genome organisation in mammalian cells : studies involving single-cell electrophoresis

    Författare :Stefan Eriksson; Bert van Zeeland; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical Biology; fysikalisk biologi;

    Sammanfattning : The comet assay (single-cell electrophoresis) is a comparably new method for measurement of DNA strand breakage, primarily in eukaryotic cells. Its main advantage is that it works on the single-cell level, making it possible to detect heterogeneity in DNA damage induction and repair. LÄS MER