Sökning: "Hereditary nonpolyposis colorectal cancer"
Visar resultat 11 - 13 av 13 avhandlingar innehållade orden Hereditary nonpolyposis colorectal cancer.
11. Molecular genetic studies on genes involved in hereditary nonpolyposis colorectal cancer (HNPCC)
Sammanfattning : Colorectal cancer (CRC) is a major public health problem in Western countries, and it is the third leading cause of death from cancer in both males and females. Inherited predisposition can be divided into two subgroups based on the absence or the presence of multiple benign colorectal polyps. LÄS MER
12. HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients
Sammanfattning : The, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. LÄS MER
13. Gastroesophageal reflux disease - complications and prognostic aspects
Sammanfattning : This thesis investigates several aspects on gastroesophageal reflux disease (GERD) and associated complications as Barrett’s esophagus and esophageal adenocarcinoma. I. To clarify the natural course of GERD, a pH-metry verified cohort was re-evaluated after 20 years. The course of GERD may well be progressive. LÄS MER