Sökning: "Hereditary colorectal"
Visar resultat 16 - 20 av 30 avhandlingar innehållade orden Hereditary colorectal.
16. Molecular genetic studies of colorectal cancer
Sammanfattning : Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality due to cancer in the Western countries. Epidemiological studies have shown that at least 20-30% of CRCs have a potentially identifiable genetic cause. LÄS MER
17. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome
Sammanfattning : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). LÄS MER
18. Investigation of genetic factors involved in colorectal cancer predisposition
Sammanfattning : Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the western world. Several hereditary CRC predisposing syndromes have been described and their genetic component has been elucidated. Taken together, these syndromes account for at most 5% of all CRC cases. LÄS MER
19. Prognostic and predictive factors for colorectal cancer
Sammanfattning : Colorectal cancer is the third most common cancer worldwide of which approximately 30% of cases are localized in the rectum. Rectal cancer accounts for around 700, 000 cases and 310, 000 deaths annually across the world with a global distribution that varies due to different lifestyles. LÄS MER
20. Significance of molecular genetic alterations and apoptosis in colorectal cancer
Sammanfattning : Colorectal cancer is a serious health problem in Western societies. In Sweden it is the second most common malignancy among females, and the third in males, and the third leading cause of cancer related death in both sexes. To date it is known that several biological pathways can lead to colorectal cancer. LÄS MER