Sökning: "Hereditary cancer"

Visar resultat 21 - 25 av 76 avhandlingar innehållade orden Hereditary cancer.

  1. 21. Insights into breast cancer: New familial patterns and identification of a potential predictive marker

    Detta är en avhandling från Division of Oncology and Pathology

    Författare :Carolina Ellberg; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; Spider telangiectasias; Heredity; Parental inheritance; Recessive; familial; Breast cancer;

    Sammanfattning : The last proportion of heredity in breast cancer has proven to be somewhat elusive despite massive attempts to identify the associated factors. Approximately 50 percent of breast cancer caused by familial factors is currently explained. LÄS MER

  2. 22. Genetic and epidemiological studies of hereditary colorectal cancer

    Detta är en avhandling från Division of Oncology and Pathology

    Författare :Kristina Cederquist; Henrik Grönberg; Irina Golovleva; Gösta Holmgren; Mef Nilbert; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lynch syndrome; HNPCC; colorectal cancer; endometrial cancer; cancer risk; MSI; MLH1; MSH2; MSH6; genome-wide scan; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) is the most common hereditary syndrome predisposing to colorectal cancer, accounting for 1-3% of all colorectal cancer. This multi-organ cancer predisposition syndrome is caused by mutations in the mismatch repair (MMR) genes, especially MLH1 and MSH2, and to lesser extents MSH6 and PMS2, which lead to widespread genetic instability and thus microsatellite instability (MSI). LÄS MER

  3. 23. Stem and progenitor cells in brain ad breast malignancies

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Gabriella Honeth; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural progenitor cells; glioma; migration; chemokines; cancer stem cells; breast cancer; CD44; CD24;

    Sammanfattning : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. LÄS MER

  4. 24. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Maria Henningson; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; familial breast cancer; premenopausal women; htSNP; GSTP1; polymorphism; BRCA1; BRCA2; IGF-1; oral contraceptives; CYP17; GSTT1; GSTM1;

    Sammanfattning : Breast cancer is the most common cancer among Swedish women, affecting more than 7000 women each year. About 5-10% of all breast cancers are hereditary, with a monogenic inheritance pattern, but only 2-4% are explained by germline mutations in BRCA1 or BRCA2. BRCA1/BRCA2 mutation carriers have a 60-80% risk of developing breast cancer. LÄS MER

  5. 25. On the genetics of hereditary breast/ovarian cancer. BRCA1, BRCA2 and beyond

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Annika Bergman; Göteborgs universitet.; Gothenburg University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; breast cancer; hereditary cancer; founder mutation; mutation analysis; linkage analysis; genome scan; BRCAX;

    Sammanfattning : Breast cancer is the most common malignancy in women. Most of the breast cancers are sporadic with no apparent inheritance factor but about 5-10% is believed to be caused by an inherited predisposition. Aims: This thesis aimed at defining the BRCA1/2 mutation spectrum of the west Swedish population and specifically to characterize the BRCA1c. LÄS MER