Sökning: "Hematopoietic development"

Visar resultat 1 - 5 av 183 avhandlingar innehållade orden Hematopoietic development.

  1. 1. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

    Författare :Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Sammanfattning : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. LÄS MER

  3. 2. Early events in T cell development

    Författare :Karin Leandersson; Malmö Cancerimmunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; pTalpha; gammadelta T cell; alphabeta T cell; development; thymus; thymocyte; serology; transplantation; Immunologi; serologi;

    Sammanfattning : T cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). LÄS MER

  4. 3. Chemokines and Integrins in Lymphocyte Development and Localization

    Författare :Jan Marsal; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; serology; Immunology; homing; development; IEL; lymphocytes; chemokines; integrins;

    Sammanfattning : The small intestine contains a large number of T lymphocytes within the single-layered epithelium that separates the gut lumen from the lamina propria. These intraepithelial T lymphocytes have potent cytolytic and immunoregulatory capacities, thought to be important for fighting infections, neoplastic growth, and sustaining epithelial integrity. LÄS MER

  5. 4. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease

    Författare :Ewa Wandzioch; Leif Carlsson; Stephen A Duncan; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; liver fibrosis; liver development; Lhx2; hematopoietic stem cells; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. LÄS MER

  7. 5. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

    Författare :Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

    Sammanfattning : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. LÄS MER