Sökning: "Hematopoietic Stem Cell Transplantation"

Visar resultat 16 - 20 av 146 avhandlingar innehållade orden Hematopoietic Stem Cell Transplantation.

1. 16. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

   Författare :Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

   Sammanfattning : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. LÄS MER

3. 17. Life situation in patients and their family members after allogeneic hematopoietic stem cell transplantation : aspects of health and support in different care settings

   Författare :Karin Bergkvist; Joacim Larsen; Jonas Mattsson; Unn-Britt Johansson; Karin Ahlberg; Sophiahemmet Högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allogeneic hematopoietic stem cell transplantation; Family member; Home care; Hospital care; Patient reported experiences; Patient reported outcomes; allogeneic hematopoietic stem cell transplantation;

   Sammanfattning : Allogeneic hematopoietic stem cell transplantation (HSCT) is mainly an intensive treatment option for hematology malignancies. During the past decades, improved care and treatment have been systematically developed. LÄS MER

4. 18. THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

   Författare :Matilda Rehn; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cells; Stem Cell Niche; Hypoxia; Hypoxia-Inducible Factor; Vegfa.;

   Sammanfattning : Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. LÄS MER

5. 19. Alloreactivity in stem cell transplantation

   Författare :Anna Nordlander; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Acute graft-versus-host disease (GVHD), relapse and graft rejection are the main complications after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this thesis was to achieve a better understanding of the alloreactivity seen after HSCT, focusing on graft rejection, but also including the graft-versus-leukemia (GVL) effect and GVHD. LÄS MER

7. 20. The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells

   Författare :Lina Thorén; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thrombopoietin; hematopoiesis; Thpo; c-kit; stem cells;

   Sammanfattning : The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per day, illustrating the high turnover within the hematopoietic system and the need for replenishments by HSCs. LÄS MER