Sökning: "Hematology"

Visar resultat 1 - 5 av 130 avhandlingar innehållade ordet Hematology.

  1. 1. Leukemia Initiation in MLL-ENL Mediated Leukemogenesis

    Detta är en avhandling från Division of Molecular Hematology (DMH)

    Författare :Amol Ugale; Lund University.; Lunds universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Luekemia; Cell of origin; Leukemia Initiation;

    Sammanfattning : In the blood system, knowledge on the regulation of hematopoietic stem cells (HSCs) and their immature progeny has provided roadmaps of differentiation. Such information can also have a value to understand the etiology of hematological cancers, since clinical heterogeneity and prognostic therapeutic outcomes have been proposed to associate with the specific developmental stage from which the transformed cells originate. LÄS MER

  2. 2. How can p53 induce differentiation of leukemic cells?

    Detta är en avhandling från Department of Hematology, Lund University

    Författare :Kristina Drott; Lund University.; Lunds universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; p53-differentiation-p21-WT1-leukemia; Hematologi; Haematology; extracellulära vätskor;

    Sammanfattning : The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. LÄS MER

  3. 3. Granulopoietic growth factors. Cytokine and cellular regulation of GM-CSF and G-CSF production

    Detta är en avhandling från Department of Hematology, Lund University

    Författare :Stig Lenhoff; Lund University.; Lunds universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; monocytes; endothelial cells; GM-CSF; G-CSF; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Granulocyte-macrophage- (GM-) and granulocyte- (G-) colony stimulating factor (CSF) are important cytokines in the regulation of hematopoiesis and for the function of mature blood cells. They are also involved in the cytokine network regulating the inflammatory and immune response. LÄS MER

  4. 4. Protease proforms as hematopoietic regulators

    Detta är en avhandling från Department of Hematology, Lund University

    Författare :Stefan Sköld; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; granulopoiesis proform PR3 NO ribonucleotide reductase; extracellular fluids; Haematology; Hematologi; extracellulära vätskor;

    Sammanfattning : A common feature in myeloid leukemia is suppression of normal hematopoiesis, leading to infections, bleeding and anemia. It has been suggested for a long time that leukemic cells possess a growth-advantage by overproducing an inhibitor - a leukamia associated inhibitor. LÄS MER

  5. 5. On the role of the fusion protein DEK-NUP214 in leukemogenesis

    Detta är en avhandling från Divison of Hematology and Transfusion Medicine

    Författare :Malin Ageberg; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA translation; Medicin människa och djur ; fusion gene; Medicine human and vertebrates ; leukemia;

    Sammanfattning : The t(6;9) translocation is found in a subset of patients with acute myeloid leukemia (AML) and is associated with a poor prognosis. The translocation results in the formation of the DEK-NUP214 fusion protein containing almost the entire nuclear protein DEK and two thirds of the nucleoporin NUP214. LÄS MER