Sökning: "Hematologi"

Visar resultat 6 - 10 av 192 avhandlingar innehållade ordet Hematologi.

  1. 6. Chronic lymphocytic leukemia : Studies on cardiovascular disease, biomarkers and subclones

    Författare :Karin Larsson; Martin Höglund; Geir Tjønnfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : Chronic lymphocytic leukemia; cardiovascular disease; population-based; biomarkers; subclones; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The treatment of Chronic lymphocytic leukemia (CLL) is rapidly changing, with targeted therapies, e.g. Bruton’s tyrosine kinase inhibitors (BTKi), entering the frontline and relapse setting. However, BTKis have significant adverse effects, most notably cardiovascular disease (CVD). LÄS MER

  3. 7. Population-based studies in Myelodysplastic syndromes : Prognostic scores, socioeconomic status, and therapy-related disease

    Författare :Daniel Moreno Berggren; Elisabeth Ejerblad; Sören Lehmann; Martin Jädersten; David Bowen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myelodysplastic syndromes; Chronic myelomonocytic leukaemia; Prognostication; Comorbidity; Therapy-related disease; Real-world data; Population-based studies; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The aim of this thesis was to expand the epidemiological knowledge of the haematological malignancy MDS and the related condition chronic myelomonocytic leukaemia (CMML). Using nationwide registers, the papers in this thesis address aspects of prognostication, comorbidity, socioeconomic status, and therapy-related disease, using a population-based approach. LÄS MER

  4. 8. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

  5. 9. Potential Hazards for Haematopoietic Stem Cell Donors

    Författare :Simon Pahnke; Hans Hägglund; Gunnar Larfors; Nina Worel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell donor; stem cell transplantation; cancer; haematology; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The aim of this thesis has been to increase our knowledge about the allogeneic stem cell donation procedure and the associated risks for stem cell donors.  In a first study (paper I), we described the donation procedure and short-term side effects of 1957 donors included in the Nordic Register of Haematopoietic Stem Cell Donors. LÄS MER

  7. 10. AL amyloidosis : Study of epidemiology, diagnosis and treatment with emphasis on heart involvement

    Författare :Sara Rosengren; Kristina Carlson; Jens Sörensen; Stefan Schönland; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin light chain AL amyloidosis; high-dose melphalan; cardiac amyloidosis; positron emission tomography PET ; incidence; population-based; Medicinsk vetenskap; Medical Science;

    Sammanfattning : AL (immunoglobulin light chain) amyloidosis is often associated with delayed diagnosis and thereby high early mortality that is not overcome by contemporary treatment. There is a need for diagnostic methods promoting earlier diagnosis, especially in patients with cardiac involvement. LÄS MER