Sökning: "Heli Rajaniemi"

Hittade 1 avhandling innehållade orden Heli Rajaniemi.

1. 1. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

   Författare :Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

   Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER