Sökning: "Helena T"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden Helena T.

  1. 1. Ancient DNA as a Means to Investigate the European Neolithic

    Författare :Helena Malmström; Anders Göterström; Gunilla Holmlund; T Brown; Uppsala universitet; []
    Nyckelord :Molecular genetics; aDNA; contamination; authentication; mtDNA; Neolithisation; Genetik;

    Sammanfattning : The transition from a hunter-gatherer lifestyle to a farming lifestyle, i.e. the Neolithisation, is arguably the most important event in human prehistory. While the geography and dating of the Neolithisation is well known, the process is still under debate, especially if it occurred through diffusion of ideas or with migrating farmers. LÄS MER

  3. 2. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

    Författare :Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. LÄS MER

  4. 3. Late Quaternary ice sheet history and dynamics in central and southern Scandinavia

    Författare :Timothy Johnsen; Helena Alexanderson; James T. Teller; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Scandinavian ice sheet; ice sheet dynamics; luminescence dating; cosmogenic exposure dating; geochronology; moraine; interstadial; deglaciation; nunatak; Quaternary geology; Kvartärgeologi; kvartärgeologi; Quarternary Geology;

    Sammanfattning : Recent work suggests an emerging new paradigm for the Scandinavian ice sheet (SIS); one of a dynamically fluctuating ice sheet. This doctoral research project explicitly examines the history and dynamics of the SIS at four sites within Sweden and Norway, and provides results covering different time periods of glacial history. LÄS MER

  5. 4. THE ROLE OF DENDRITIC CELLS AND TYPE I INTERFERON IN THE GENERATION AND FUNCTION OF T FOLLICULAR HELPER CELLS

    Författare :Helena Cucak; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T follicular helper cells; Type I interferon; Dendritic cells;

    Sammanfattning : Generation of long-lived plasma cells and memory B cells of high affinity takes place in germinal centers and depends on help from a specialized CD4+ T cell subset termed T follicular helper (Tfh) cells. These processes are crucial for long-term protection upon natural infection or in settings of vaccination, however they are also responsible for development of antibody-mediated autoimmune disease. LÄS MER

  7. 5. Biomarkers in sepsis and other severe infections

    Författare :Helena Janols; Enheten för infektionssjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunosuppression; myeloid-derived suppressor cells; T cells; dendritic cells; monocytes; sepsis; Biomarkers;

    Sammanfattning : Infectious diseases constitute a major global health problem. The presenting clinical picture results from a mixture of direct toxic actions by the microbiological agent and of the immune response mounted by the host. LÄS MER