Sökning: "Helena Harris"

Hittade 2 avhandlingar innehållade orden Helena Harris.

  1. 1. Studies of the immunopathogenesis in three arthritis models in rats

    Författare :Helena Erlandsson Harris; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :experimental arthritis; inflammation; adjuvants; T-cell receptor; collagen type II; cartilage oligomeric matrix protein COMP ;

    Sammanfattning : The immunopathogenesis of three arthritis models has been studied; oil-induced arthritis (OIA), homologous collagen-induced arthritis (CIA) and COMP-induced arthritis. The induction of a monophasic arthritis, OIA, in the DA rat with a single intradermal injection of Freund's incomplete adjuvant (FIA) was reported. LÄS MER

  3. 2. Modulation of B cell access to antigen by passively administered antibodies : an explanation for antibody feedback regulation?

    Författare :Hui Xu; Birgitta Heyman; Helena Harris; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

    Sammanfattning : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. LÄS MER