Sökning: "Heldin"

Visar resultat 1 - 5 av 48 avhandlingar innehållade ordet Heldin.

  1. 1. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    Författare :Merima Mehić; Paraskevi Heldin; Carl-Henrik Heldin; Liliana Schaefer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. LÄS MER

  3. 2. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer

    Författare :Angelos Heldin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. LÄS MER

  4. 3. Tartaric acid derivatives as chiral selectors in liquid chromatography

    Författare :Eva Heldin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  5. 4. Identification and Characterization of Proteins and MicroRNAs that Modulate Receptor Signaling, Vesicular Trafficking and Cell Migration in Vascular Cells

    Författare :Johan Heldin; Johan Kreuger; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; cell migration; signaling; VEGF; FGD5; ExoC3L2; microRNA; RhoD; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Blood vessels deliver nutrients and oxygen to tissues. Importantly, the functions and growth of blood vessels are commonly altered in disease. The inside of all blood vessels are lined with endothelium, a thin specialized layer of endothelial cells that separate the blood from other tissues. LÄS MER

  7. 5. Designing grinding tools to control and understand fibre release in groundwood pulping

    Författare :Magnus Heldin; Urban Wiklund; Birgitta Engberg; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Groundwood pulping; Grinding mechanisms; Diamond grinding tool; Energy efficiency; Teknisk fysik med inriktning mot tribomaterial; Engineering Science with specialization in Tribo Materials;

    Sammanfattning : Mechanical pulping is a very energy demanding process in which only a fraction of the energy is used for the actual separation of wood fibres. The rest of the energy is lost, partly in damaging already separated fibres and partly as heat during viscoelastic deformation of the wood. LÄS MER