Sökning: "Hedgehog pathway"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Hedgehog pathway.

  1. 1. Repressing the hedgehog signalling pathway

    Författare :Jessica Svärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal cell carcinoma (BCC) and medulloblastoma (MB). LÄS MER

  3. 2. Predictive and prognostic factors in cervical carcinomas treated with (chemo-) radiotherapy

    Författare :Louise Bohr Mordhorst; Bengt Sorbe; Preben Kjölhede; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical carcinoma; radio-chemotherapy; biomarkers; predictive factors; prognostic factors; multiprotein analysis; Hedgehog pathway; Wnt β-catenin pathway; Surgery; Kirurgi;

    Sammanfattning : A series of 131 women with cervical carcinoma FIGO stage I-IV were treated with external radiotherapy and intracavitary brachytherapy. In 47 patients (36%) concomitant chemotherapy was given. One hundred and twenty-one tumors (92%) achieved complete remission. Addition of chemotherapy increased primary cure rate to 98%. LÄS MER

  4. 3. Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential

    Författare :Ani Azatyan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog signaling are not completely understood. LÄS MER

  5. 4. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

    Författare :Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER

  7. 5. From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster

    Författare :Shai Mulinari; Sociologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Odd-skipped; morphogenesis; Hedgehog; segment boundaries; segmental grooves; Actin; Drosophila; DRhoGEF2; Myosin; Diaphanous; Rho GTPase; cytoskeleton; Rho1;

    Sammanfattning : Embryonic development is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. LÄS MER