Sökning: "Ha-ras"

Hittade 3 avhandlingar innehållade ordet Ha-ras.

1. 1. Studies of induced transcription in response to an activated Ha-ras, TPA and UV radiation in keratinocytes

   Författare :Mats Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :keratinocytes; Ha-ras; ultraviolet radiation; transcription factor; TPA; NF-kB;

   Sammanfattning : The mutational activation of the Ha-ras gene in keratinocytes has been shown to occur during the initiation step in the mouse skin model for multistage carcinogenesis. Skin tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and ultraviolet radiation (UVR) stimulate a selective outgrowth of initiated keratinocytes to form benign tumours (papillomas). LÄS MER

3. 2. Molecular factors relevant to the radiosensitivity of human tumours

   Författare :Anya Polischouk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :c-Ha-ras; c-myc; radiosensitivity; DNA double-strand break repair; DNA singlestrand repair;

   Sammanfattning : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. LÄS MER

4. 3. NF-kB in epidermal signal transduction and tumor development

   Författare :Max van Hogerlinden; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology and epidermal tumor development are largely unknown. LÄS MER