Sökning: "HMGCR"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet HMGCR.

  1. 1. Statins, HMGCR and Breast Cancer

    Författare :Olöf Bjarnadottir; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Statins; HMGCR; Cyclin D1; p27; Clinical trial; Gene expressionprofiling; cholesterol-lowering medication;

    Sammanfattning : .... LÄS MER

  3. 2. The role of HMG-coenzyme A reductase (HMGCR) and statin medication in the Central Nervous System : Cognitive Functions, Metabolism, Feeding and Sleep Behaviour

    Författare :Ahmed Alsehli; Helgi B. Schiöth; Michael J. Williams; Heinrich Dircksen; Uppsala universitet; []
    Nyckelord :Statin; cardiovascular disease; HMGCR; PCSK9; sleep; insomnia; circadian; Chronotype; feeding;

    Sammanfattning : Millions of people are currently on statin medications (HMGCR inhibitors) to prevent cardiovascular diseases. Despite considerable central nervous system expression, little is known about HMGCR function in the brain. LÄS MER

  4. 3. Body constitution, statin use, and tumor characteristics. Implications for prognosis

    Författare :Helga Tryggvadottir; Epidemiologi och farmakogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; prognosis; tumor-specific markers; HMG-CoA reductase; aryl hydrocarbon receptor; aromatase; statins; anthropometric factors;

    Sammanfattning : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. LÄS MER

  5. 4. Adverse drug effects on glucose and lipid metabolism: is human adipose tissue of importance?

    Författare :Assel Sarsenbayeva; Jan Eriksson; Mikael Rydén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human adipose tissue; metabolic adverse effects; SGAs; statins; glucocorticoids; glucose uptake; lipolysis; myofibroblasts; fibrosis; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Many pharmacological agents that are widely prescribed in clinical practice have adverse metabolic effects, such as hyperglycaemia, insulin resistance, and diabetes. Among such drugs are antipsychotics, prescribed for treatment of schizophrenia; statins, which inhibit cholesterol synthesis and prevent cardiovascular events; finally, potent anti-inflammatory agents, glucocorticoids. LÄS MER

  7. 5. Targeting the role of statins in breast cancer – through translationally edged clinical trials

    Författare :Maria Feldt; Bröstcancer - prevention & intervention; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : AbstractBreast cancer incidence is increasing, and despite major progress in the treatment, breast cancer is still the leading cause of death from cancer among women. Thus, there is a constant need for new treatment options. LÄS MER