Sökning: "HMGB1"

Visar resultat 6 - 10 av 49 avhandlingar innehållade ordet HMGB1.

  1. 6. Danger within : HMGB1 as a mediator of arthritis

    Författare :Erik Sundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic arthritis occurs in childhood as juvenile idiopathic arthritis and in adults most commonly as rheumatoid arthritis. The clinical expression of these diseases differ and it is presently unknown to what extent they share pathogenic mechanisms. Optimal modes of therapy in adults generally coincide with those in children. LÄS MER

  3. 7. Multiple roles of HMGB1 in clinical and experimental arthritides

    Författare :Hanna Schierbeck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation can be infectious and/or sterile depending on the initiating event. The proinflammatory mediator High mobility group box protein 1 (HMGB1) is a nuclear protein released from cells during both sterile and infectious inflammation and once extracellular, initates and potentiates inflammation by inducing cytokine production and by recruiting inflammatory cells. LÄS MER

  4. 8. Role of spinal and peripheral HMGB1 in arthritis-induced pain

    Författare :Nilesh Mohan Agalave; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain remains a major problem for a subgroup of patients. LÄS MER

  5. 9. Following the white rabbit : release and regulation of HMGB1 in inflammation

    Författare :Agnieszka Sowinska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein (HMGB1), is primarily bound to DNA in the nucleus of most eukaryotic cells. LÄS MER

  7. 10. Life after intensive care-post : intensive care syndrome, inflammation, and HMGB1

    Författare :Emily Brück; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Survival rates of intensive care unit (ICU) patients are consistently increasing. This new patient population has recently gained increased recognition as they suffer from psychological, physical, and cognitive impairments in the years to come after ICU discharge. LÄS MER