Sökning: "HMGB1"

Visar resultat 16 - 20 av 49 avhandlingar innehållade ordet HMGB1.

1. 16. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

   Författare :Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

   Sammanfattning : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. LÄS MER

3. 17. Macrophages : as central inflammatory mediators and as targets for therapeutic interventions

   Författare :Åsa Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Macrophages; HMGB1; IL-23; MS; EAE; autoimmunity.;

   Sammanfattning : Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory actions, Mphis also have distinct roles in disease resolution, and effective therapeutic targeting of Mphi-expressed molecules requires understanding of the interplay between different Mphi activators and the kinetics of the induced responses. LÄS MER

4. 18. Aspects of immune activation in HIV-1 infection

   Författare :Piotr Nowak; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immune activation; HMGB1; PHI; HIV-1 LTR-transcription; cytokines; chemokines;

   Sammanfattning : Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under antiretroviral therapy (ART). LÄS MER

5. 19. HMBG1 and other soluble factors in HIV-1 pathogenesis

   Författare :Babilonia Barqasho; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; PHI; cytokines; chemokines; immune activation; HMGB1; cell death;

   Sammanfattning : The innate immune system is the first defense mechanism invading pathogens encounter. Macrophages, dendritic cells and cytokines/chemokines are important factors for the functionality of the innate immunity, and provide the adaptive immune system with sufficient signals for the proper action. LÄS MER

7. 20. Adult neural stem cells in neuroinflammation

   Författare :Ruxandra Covacu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neural stem cells; inflammation; EAE; NO; neurogenesis; HMGB1; TLR; TNFalpha;

   Sammanfattning : Adult neural stem cells (NSC) can be isolated from the subventricular zone (SVZ) of the lateral ventricles, the subgranular zone (SGZ) of the hippocampus and the central canal of the spinal cord. These cells are thought to have regenerative potential and pose important therapeutic possibilities in neuroinflammatory conditions such as Multiple Sclerosis (MS). LÄS MER