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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.
1. Immunological recognition and tumor escape mechanisms of ovarian carcinoma
Sammanfattning : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. LÄS MER
2. Mechanisms of immune escape : implications for immunotherapy against cancer
Sammanfattning : Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells that acquire a less immunogenic phenotype. LÄS MER
3. Recurrent spontaneous abortion : a clinical, immunological and genetic study
Sammanfattning : Recurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies before 20 completed gestational weeks. The condition affects 0.5-1% of all women. In the majority of women with RSA, the cause remains unexplained after genetic, endocrine, immunological and anatomical investigations of the couple. LÄS MER
4. HLA-A*02 and its prognostic traits in cancer : an immunological biomarker as a tool towards individualised cancer therapy
Sammanfattning : This thesis is based on the findings that HLA-A*02, a common allele in the Swedish population, has a decreasing frequency in the European continent in relation to geographic latitude. Furthermore, mortality of ovarian cancer correlates to the HLA-A*02 frequency and geographic latitude. LÄS MER
5. The role of HLA-A*02 and biomarkers in solid malignant tumours
Sammanfattning : HLA-A*02 genotype generates significantly worse outcome in patients with metastatic serous ovarian cancer and malignant melanoma. HLA-A*02 is common in the Swedish population (about 60 %), but has decreasing frequency in European countries further south. LÄS MER