Sökning: "HLA-G"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet HLA-G.

  1. 1. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

    Författare :Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

    Sammanfattning : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. LÄS MER

  3. 2. Mechanisms of immune escape : implications for immunotherapy against cancer

    Författare :Karl-Johan Malmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor Immunology; Immune escape; NK receptors; T lymphocytes; Oxidative stress; Vitamin E;

    Sammanfattning : Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells that acquire a less immunogenic phenotype. LÄS MER

  4. 3. Recurrent spontaneous abortion : a clinical, immunological and genetic study

    Författare :Barbara Jablonowska; Ole Christiansen B.; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Recurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies before 20 completed gestational weeks. The condition affects 0.5-1% of all women. In the majority of women with RSA, the cause remains unexplained after genetic, endocrine, immunological and anatomical investigations of the couple. LÄS MER

  5. 4. HLA-A*02 and its prognostic traits in cancer : an immunological biomarker as a tool towards individualised cancer therapy

    Författare :Lisa Villabona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is based on the findings that HLA-A*02, a common allele in the Swedish population, has a decreasing frequency in the European continent in relation to geographic latitude. Furthermore, mortality of ovarian cancer correlates to the HLA-A*02 frequency and geographic latitude. LÄS MER

  7. 5. The role of HLA-A*02 and biomarkers in solid malignant tumours

    Författare :Emilia Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HLA-A*02 genotype generates significantly worse outcome in patients with metastatic serous ovarian cancer and malignant melanoma. HLA-A*02 is common in the Swedish population (about 60 %), but has decreasing frequency in European countries further south. LÄS MER