Sökning: "HLA-DRB1"

Visar resultat 6 - 10 av 68 avhandlingar innehållade ordet HLA-DRB1.

  1. 6. Studies of risk loci in multiple sclerosis

    Författare :Magdalena Lindén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system, is one of the most common causes of neurological disability among young adults. While the etiology is unknown, an increasing number of environmental and genetic risk factors is being identified. LÄS MER

  3. 7. Specific autoimmunity in rheumatoid arthritis : T cells, antibodies and genetic regulation

    Författare :Omri Snir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Complex interactions between genes and environmental factors may result in destruction of the body’s own cells and tissues by the immune system, i.e. autoimmunity. Rheumatoid arthritis (RA) is a chronic joint inflammation mediated by all arms of the immune system that can lead to tissue destruction and functional disabilities. LÄS MER

  4. 8. Conquering complexity : successful strategies for finding disease genes in multiple sclerosis

    Författare :Kerstin Imrell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a complex disease; at an intra-individual level several contributory factors cause the disease; at an inter-individual level different factors contribute to the disease. The aim of the thesis project was to reduce this complexity by focusing of subsets of patients that were likely to share to a higher extent contributory causes and to identify in these subsets genes conferring susceptibility. LÄS MER

  5. 9. Gene expression profiling in autoimmune diseases : a story of ups and downs

    Författare :Miranda Houtman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are believed to arise from a combination of genetic and environmental factors that affect normal function of immune cells. In this thesis, we studied the functional role of genetic variants, in peripheral blood cells, that relate to rheumatoid arthritis (RA) and myositis by gene expression profiling. LÄS MER

  7. 10. HLA genetics in multiple sclerosis

    Författare :Jenny Link; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic disease in which both genetic and environmental risk factors contribute to disease susceptibility. MS patients suffer from inflammatory lesions in the central nervous system which results in demyelination of nerve cells, reduced neuronal activity and finally neurodegeneration. LÄS MER