Sökning: "HLA-DRB1"

Visar resultat 21 - 25 av 68 avhandlingar innehållade ordet HLA-DRB1.

  1. 21. Anti-drug antibodies in patients with multiple sclerosis

    Författare :Malin Ryner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is an inflammatory disease affecting the brain and spinal cord and it is the main cause of neurological disability among young adults. Recombinant interferon beta (IFNβ) and natalizumab are commonly used disease-modifying drugs that reduce disease severity. LÄS MER

  3. 22. Genetic studies of glomerulonephritis with special focus on IgA nephropathy and Lupus nephritis

    Författare :Mai Tuyet Vuong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : IgA nephropathy and nephritis in Systemic Lupus Erythematosus (SLE) are two common forms of glomerulonephritis with unknown etiology. As for many other complex diseases, both genetic and environmental factors could be of importance for disease development. LÄS MER

  4. 23. The risk of developing rheumatoid arthritis : epidemiological studies on associations with socioeconomic status, psychosocial work stress and smoking

    Författare :Camilla Bengtsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic, inflammatory disease. Knowledge about the contribution of genetics is rapidly increasing, but data on environmental factors that may cause RA is scarce. LÄS MER

  5. 24. Markers of inflammation and neurodegeneration in muliple sclerosis

    Författare :Virginija Danylaitė Karrenbauer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main line of my thesis projects is searching for biomarkers and evidence of optimal correlation with clinical and para-clinical outcome measurements in multiple sclerosis (MS): investigating the biochemical biomarker in blood/plasma (cerebrosterol) and in cerebrospinal fluid (CSF) (oligoclonal bands (OCB)) and the correlation with MRI lesion load (paper 1 and paper IV); investigating the genetic biomarker (CYP46A1) for susceptibility and disability progression in MS (Paper III); comparison of the well-known positron emission tomography (PET) ligand and peripheral benzodiazepine receptor (PBR) antagonist, [11C]PK11195, and a new PET ligand [11C]vinpocetine (tissue receptor biomarker). Both ligands denote areas of active ongoing inflammation in MS (paper II). LÄS MER

  7. 25. Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)

    Författare :Taotao Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. LÄS MER