Sökning: "HIV"

Visar resultat 6 - 10 av 644 avhandlingar innehållade ordet HIV.

1. 6. Structural Studies of Bacteriophage PRR1 and HIV-1 protease

   Författare :Magnus Persson; Lars Liljas; Kaspars Tars; Félix Rey; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRR1; HIV; Structural Biology; X-ray crystallography; PRR1; HIV-1 protease; NCS; crystallography; inhibitor; virus; bacteriophage; X-ray crystallography; Virology; Virologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : Viruses are a diverse genera of organisms adapted to thrive in many different hosts from prokaryotic to eukaryotic.We present here the structure of bacteriophage PRR1 virus-like particle (VLP), belonging to Leviviridae family. Our structure reveals calcium ions in the VLP. LÄS MER

3. 7. HIV and Infant Feeding : Operational Challenges of Achieving Safe Infant Feeding Practices

   Författare :Tanya Doherty; Lars-Åke Persson; Ted Greiner; Debra Jackson; Per Ashorn; Uppsala universitet; []
   Nyckelord :International health; HIV AIDS; Prevention of Mother to Child Transmission of HIV; infant feeding; child health; qualitative research; cohort study; programme evaluation; nutrition; Internationell hälsa;

   Sammanfattning : This thesis assesses the uptake of the national Prevention of Mother to Child Transmission of HIV (PMTCT) programme in South Africa, and the challenges of achieving safe infant feeding practices in the context of HIV. The research studies contained in this thesis utilised a variety of quantitative and qualitative research methods in order to provide a full understanding of the challenges of moving from efficacy to effectiveness in PMTCT programmes. LÄS MER

4. 8. Sexuality in women living with HIV

   Författare :Ewa Carlsson-Lalloo; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; Childbearing; Sexuality; Women;

   Sammanfattning : The overall aim was to investigate different aspects of sexuality in women living with HIV in Sweden. Study I was a meta-synthesis of 18 qualitative studies describing experiences of sexuality and reproduction in women living with HIV. LÄS MER

5. 9. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling

   Författare :Anna Ax; Anders Karlén; Anders Hallberg; Tommy Liljefors; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; AIDS; HIV; protease inhibitor; aspartic protease; molecular modelling; 3D-QSAR; CoMFA; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER

7. 10. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

   Författare :Johan Wannberg; Anders Hallberg; David C. Rees; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Sammanfattning : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. LÄS MER