Sökning: "HIV-1 protease"

Visar resultat 16 - 20 av 65 avhandlingar innehållade orden HIV-1 protease.

1. 16. The effect of alpha-HGA on HIV-1 replication

   Författare :Masoud Youssefi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; p24; capsid formation; alpha-HGA; antiretroviral; uptake;

   Sammanfattning : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. LÄS MER

3. 17. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

   Författare :Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
   Nyckelord :Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

   Sammanfattning : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. LÄS MER

4. 18. Primary HIV-1 infection : diagnostic, prognostic, and therapeutic aspects

   Författare :Stefan Lindbäck; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :primary HIV- I infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment; primary HIV-1 infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment;

   Sammanfattning : Primary HIV-1 infection (PHI) is usually defined as a mononucleosis-like illness associated with seroconversion to HIV. In earlier studies using 1st generation antibody tests, the duration of the 'window period' from infection to detection of specific HIV-antibodies, could be 2 to 3 months, or longer. LÄS MER

5. 19. Structure-activity and resistance studies of HIV-1 protease inhibitors

   Författare :Göran Ahlsén; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : The present investigation was undertaken in order to identify inhibitors of HIV-1 protease that would be efficient in vivo and against HIV-1 protease carrying mutations known to confer resistance to inhibitors in clinical use. A second interest was to understand details of inhibitory mechanisms and to gain understanding of the molecular details of resistance. LÄS MER

7. 20. Improving the immunogenicity of HIV-1 DNA vaccines

   Författare :David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nearly 30 years have passed since the start of the global HIV epidemic and we are still unable to control the spread of the virus. HIV predominately infects cells crucial for the function of the immune system, integrates into the host genome and demonstrates a huge genetic variability, and the use of therapeutic antiretroviral drugs can restrain but not clear the infection. LÄS MER