Sökning: "HIV-1 LTR-transcription"

Hittade 2 avhandlingar innehållade orden HIV-1 LTR-transcription.

1. 1. Regulation of HIV-1 provirus transcription

   Författare :Mojgan H Naghavi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Key words- HIV-1; LTR; transcription; subtypes; phylogenetic analysis; NFkappaB; USF; MCEF; HMG-1 DSP1; Dorsal.;

   Sammanfattning : Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus activation. LÄS MER

3. 2. Aspects of immune activation in HIV-1 infection

   Författare :Piotr Nowak; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immune activation; HMGB1; PHI; HIV-1 LTR-transcription; cytokines; chemokines;

   Sammanfattning : Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under antiretroviral therapy (ART). LÄS MER