Sökning: "HIT-T15 cells"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden HIT-T15 cells.

  1. 1. Insulin-Producing Cells, Iron, Oxidative Stress, and Lysosomal Pathology

    Författare :Beata Teresa Olejnicka; Enrique Cadenas; Linköpings universitet; []
    Nyckelord :Insulin-producing cells; redox-active iron; oxidative stress; lysosomes; desfenioxamine; MEDICINE; MEDICIN;

    Sammanfattning : Accumulating evidence suggests that injnries caused by oxygen-derived radicals contribute to the destruction of pancreatic islet ß-cells in autoinnnune diabetes mellitus (diabetes type I, or IDDM). Oxidative stress may be caused by an enhanced production of oxygen-derived radicals, or by a decreased scavenging of such molecules. LÄS MER

  3. 2. Intracellular signaling of phosphorylated insitol compounds : a study in pancreatic beta-cells and hippocampal neurons

    Författare :Jia Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :InsP6; L-type Ca 2 channel; hippocampal neuron; Ins 1; 4; 5 P3; Ca2 ; cyt-MIPP; pancreatic beta-cell; PtdIns 3; 4; 5 P3; Ptdlns 3; 5 P2.;

    Sammanfattning : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. LÄS MER

  4. 3. Effects of imidazoline compounds on intracellular CA2+ and apoptosis

    Författare :Ioulia Appelskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :imidazolines; imidazoline site; sulfonylurea; glucose; interleukin-1beta; insulin secretion; glucagon; somatostatin; pancreatic islets; pancreatic P-cells; HIT-T15 cells; apoptosis; cytoplasmic free Ca2 concentration;

    Sammanfattning : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. LÄS MER

  5. 4. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

  7. 5. Stimulation of insulin secretion independently from changes in cytosolic free Ca²+-concentration : studies with imidazolines and inositol polyphosphates

    Författare :Alexander Efanov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :insulin secretion; pancreatic ß-cell; imidazolines; inositol polyphosphates;

    Sammanfattning : Insulin secretion from the islets of Langerhans is regulated by changes in glucose concentration. Glucose stimulates secretion by two mechanisms. First, it increases cytosolic free Ca2+ concentration ([Ca2+]i) by inhibition of ATP-dependent K+-channels (KATP) and induction of membrane depolarization. LÄS MER