Sökning: "HIF-1alpha"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet HIF-1alpha.

  1. 1. Analysis of HIF-1alpha degradation and function

    Författare :Helder André; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

    Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER

  3. 2. Oxygen-dependent regulation of HIF-1alpha expression and function

    Författare :Xiaowei Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. LÄS MER

  4. 3. Expression, regulation and fuction of small ubiquitin-related modifier-1. Interaction with nuclear proteins in vivo

    Författare :Linus Ruijin Shao; Göteborgs universitet; []
    Nyckelord :SUMO-1; LH receptor; PR isoforms; caspase-3; DNA fragmentation; apoptosis; granulosa cells; HIF-1alpha; hypoxia; brain and heart;

    Sammanfattning : The small ubiquitin-related modifier-1 (SUMO-1) is a 101-amino acid, ~12 kDa protein that is 18% identical to ubiquitin. Posttranslational covalent tagging of proteins with SUMO-1 (SUMOylation) serves many functions. For example, regulation of protein stability and modulation of transcriptional activation. LÄS MER

  5. 4. The role of HIF-1alpha in epigenetic regulation of transcription

    Författare :Nikola Vojnovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating HIF protein stability. LÄS MER

  7. 5. Assessment of HIF-1alpha function and identification of a novel degradation mechanism

    Författare :Helder André; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF-1alpha and ARNT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER