Sökning: "HIF-α"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet HIF-α.

1. 1. The role of transforming growth factor‐β signaling and hypoxia‐inducible factors in renal cell carcinoma

   Författare :Pramod Mallikarjuna; Maréne Landström; Börje Ljungberg; Raviprakash Tumkur Sitaram; Anders Bjartell; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; Hypoxia; Renal cell carcinoma; ccRCC; non-ccRCC; transforming growth factor-β; ALK5; pVHL; HIF-α; SNAIL1; molekylärbiologi; Molecular Biology;

   Sammanfattning : Renal cell carcinoma (RCC) is the cancer of the kidneys; about 1100 patients with RCC are diagnosed in Sweden each year. RCC can be classified into several subtypes, clear cell renal cell carcinoma (ccRCC) is most common accounting to about 70% of all RCCs, and also the most lethal; papillary renal cell carcinoma (pRCC) accounts to about 10%‐15%, while chromophobe renal cell carcinoma (chRCC) accounts to about 5% of all RCCs. LÄS MER

3. 2. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

   Författare :Karolina Helczynska; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

   Sammanfattning : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. LÄS MER

4. 3. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

   Författare :Anna-Maria Larsson; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Anemia; Hypoxia; Erythropoietin EPO ; EPO receptor EPOR ; Estrogen Receptor ER ; Hypoxia-Inducible Factors HIFs ; Tamoxifen Response; Proliferation;

   Sammanfattning : The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. LÄS MER

5. 4. New pathogenic mechanisms in diabetic wound healing

   Författare :Vivekananda Sunkari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Diabetic foot ulcers (DFU) represent one of the most feared and invalidating complication of diabetes with high financial pressure for the healthcare system. For the moment there is no specific therapy available and it has become a priority to develop novel rational therapeutic strategies based on new pathophysiological mechanisms. LÄS MER

7. 5. Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling

   Författare :Ileana Ruxandra Botusan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology and pathology to be able to design therapies for several diseases where angiogenesis is dysregulated (either excessive or diminished). LÄS MER