Sökning: "HER2 neu"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden HER2 neu.

  1. 1. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

    Författare :Yang Rongcun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

    Sammanfattning : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. LÄS MER

  3. 2. Vaccination against Her2/neu : expressing cancer using chimeric virus-like particles

    Författare :Kalle Andreasson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thanks to the development of vaccines, children are these days protected against infectious diseases like polio, diphtheria and tetanus simply by receiving a few injections. Imagine a scenario where these injections would also result in protection against cancer. LÄS MER

  4. 3. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

    Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

    Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

  5. 4. Cancer therapy using viral and bacterial proteins as vectors for vaccines or as carriers of cytostatics

    Författare :Mathilda Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : New cancer therapies are urgently needed, since available treatment options today have negative side effects, and cure only about half of the patients with invasive cancer. One, relatively new, option is to vaccinate against cancer, by introducing an antigen that is present on the tumor cells into the patient to stimulate specific immunity against the tumor. LÄS MER

  7. 5. Rational and combinatorial protein engineering for vaccine delivery and drug targeting

    Författare :Maria Wikman; Stefan Ståhl; Carl A. K. Borrebaeck; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; affibody; affinity chromatography; biotin; combinatorial; delivery; phage display; Biomedicin; Microbiology; Mikrobiologi;

    Sammanfattning : This thesis describes recombinant proteins that have been generated by rational and combinatorial protein engineering strategies for use in subunit vaccine delivery and tumor targeting.In a first series of studies, recombinant methods for incorporating immunogens into an adjuvant formulation, e.g. LÄS MER