Sökning: "HCMV"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet HCMV.

  1. 1. Human cytomegalovirus (HCMV) : detection and elimination of infected blood cells in vitro, immune reactivity and complications following HCMV infection

    Författare :Susanne Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human cytomegalovirus (HCMV) belongs to the herpes virus family and establishes life-long persistence in a latent state following a primary infection. HCMV disease causes high morbidity in immunosuppressed individuals, such as bone marrow and organ transplant patients. LÄS MER

  3. 2. HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?

    Författare :Atosa Estekizadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented in several cancer types. LÄS MER

  4. 3. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development

    Författare :Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). LÄS MER

  5. 4. Human cytomegalovirus (HCMV) infection in patients with inflammatory bowel diseases (IBD) : role in pathogenesis and autoimmunity

    Författare :Afsar Rahbar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human cytomegalovirus; Inflammatory bowel diseases; auto-antibodies; blood platelets; PMNL;

    Sammanfattning : Human cytomegalovirus (HCMV) is one of eight members of the herpesvirus family that infects humans. Like other herpes viruses, HCMV establishes a latent infection after the primary infection, and reactivation may occur later in life. LÄS MER

  7. 5. Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?

    Författare :Michel Silvestri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CMV; HCMV; gB; autoimmunity; cross-reactivity; epitope analysis electrochemiluminescence; heparin; heparan sulphate; neutralising antibodies;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a significant factor in morbidity, why there is clearly a need for effective therapy and prophylaxis against HCMV infection. LÄS MER