Sökning: "H3K27"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet H3K27.

  1. 1. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

    Författare :Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

    Sammanfattning : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. LÄS MER

  3. 2. Towards forecasting epigenetic repression

    Författare :Moa J. Lundkvist; Yuri B. Schwartz; Ludvig Lizana; Peter V. Kharchenko; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; epigenetics; Polycomb; PRC1; PRC2; H3K27 methylation; Monte-Carlo simulation; chromatin structure; Drosophila; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Sammanfattning : Multicellular organisms form many different cell types from one genome, which requires differential gene activity. The Polycomb system upholds the correct gene expression programs by epigenetically silencing genes that encode critical transcription regulators. LÄS MER

  4. 3. Studies on the regulation and function of lipoxygenases in Hodgkin lymphoma

    Författare :Hongya Han; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hodgkin lymphoma (HL) is a unique entity among the lymphomas, with a minority of malignant Hodgkin and Reed-Sternberg (H-RS) cells surrounded by a broad range of infiltrating cells. The infiltration of certain inflammatory cells has been reported to predict prognosis of the disease. LÄS MER

  5. 4. From stem cell to neuron : a Sox perspective

    Författare :Maria Bergsland; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The differentiation of stem cells into the more than 100 billion neurons that compose the central nervous system (CNS) is one of the most remarkable transformations during vertebrate development. A central problem of this process is how neural lineage selection initially is specified in pluripotent stem cells and maintained during the course of neurogenesis. LÄS MER

  7. 5. Genetic and epigenetic mechanisms underlying the regulation of flowering time

    Författare :Lejon Kralemann; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Developmental transitions and responses to the environment have a tight epigenetic control. Especially the switch to flowering is important for plants because it allows (sexual) reproduction, and should not occur unless the conditions are right. LÄS MER