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1. 1. Structure-function studies of plasminogen activator inhibitor-1

   Författare :Guang-Chao Sui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PAI-1; site-directed mutagenesis; structure and function; stability;

   Sammanfattning : Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic disease, and low levels can be connected to a bleeding tendency. LÄS MER